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It is now clear that both centrioles and their surrounding pericentriolar material (PCM) are capable of self-assembly. Whereas centrioles are normally duplicated during G1-S phase, PCM components may be loaded onto centrosomes in both a microtubule-dependent and -independent manner at all stages of the cell cycle. Centrosomes enlarge dramatically after mitotic entry, when both Aurora A and Polo-like kinases cooperate to recruit additional gamma-tubulin ring complexes and microtubule-associated proteins to assist spindle formation.

Original publication

DOI

10.1038/ncb0603-505

Type

Journal article

Journal

Nat Cell Biol

Publication Date

06/2003

Volume

5

Pages

505 - 511

Keywords

Animals, Aurora Kinases, Centrioles, Centrosome, Drosophila Proteins, Dyneins, Humans, Microtubule-Associated Proteins, Microtubules, Mitosis, Models, Biological, Protein-Serine-Threonine Kinases, Tubulin