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The RNA binding protein Larp1 was originally shown to be involved in spermatogenesis, embryogenesis and cell-cycle progression in Drosophila. Our data show that mammalian Larp1 is found in a complex with poly A binding protein and eukaryote initiation factor 4E and is associated with 60S and 80S ribosomal subunits. A reduction in Larp1 expression by siRNA inhibits global protein synthesis rates and results in mitotic arrest and delayed cell migration. Consistent with these data we show that Larp1 protein is present at the leading edge of migrating cells and interacts directly with cytoskeletal components. Taken together, these data suggest a role for Larp1 in facilitating the synthesis of proteins required for cellular remodelling and migration.

Original publication

DOI

10.1093/nar/gkq294

Type

Journal article

Journal

Nucleic Acids Res

Publication Date

09/2010

Volume

38

Pages

5542 - 5553

Keywords

Actins, Apoptosis, Autoantigens, Cell Movement, Cytoskeletal Proteins, Eukaryotic Initiation Factor-4E, HeLa Cells, Humans, Mitosis, Peptide Chain Initiation, Translational, Poly(A)-Binding Proteins, Pseudopodia, Ribonucleoproteins