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Two articles in this issue (Intlekofer et al., 2015; Oldham et al., 2015) show a new metabolic pathway regulated by hypoxia, but independently of HIF1 or HIF2. L-2-hydroxyglutarate, produced in hypoxia by malate dehydrogenases and LDHA, is a potent inhibitor of KDM4C, and through redox stress reduces glycolysis.

Original publication

DOI

10.1016/j.cmet.2015.07.016

Type

Journal article

Journal

Cell Metab

Publication Date

04/08/2015

Volume

22

Pages

198 - 200