Personalised Cancer Medicine: Fulfilling the Promise
Olzscha H., New M., LaThangue NB.
The continual increase in global cancer incidence has created a huge need for new and more effective cancer drugs. However, success is often limited by the heterogeneity among patients, which frequently leads to the failure of patients to respond to a drug together with toxic side effects. Personalised medicine uses our advancing molecular understanding of disease to provide the most efficient medical care for individual patients, depending on their unique clinical, genetic and environmental state. Various types of biomarkers assist this process by enabling prediction of clinical outcome on treatment, or measuringeffect of treatmentwhichis then correlated with a clinical endpoint. Omics technologies such as genomics, transcriptomics and proteomics are crucially important in the personalised medicine approach as they enable the analysis of multiple and large datasets to stratify patients into responder subgroups.