IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning.
Crijns W., Budiharto T., Defraene G., Verstraete J., Depuydt T., Haustermans K., Van den Heuvel F.
This paper reports on an evaluation of 5 RapidArc optimization approaches vs IMRT. This study includes 11 patients with adenocarcinoma of the prostate. Rectal Normal Tissue Complication Probability is used as a constraint in a dose escalation. RapidArc rectal NTCP's are lower than those of IMRT (p = 0.007). This allows a mean dose escalation of 2.1 Gy([0.7 Gy,3.5 Gy]).