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Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.

Original publication




Journal article


Cell Mol Life Sci

Publication Date





3249 - 3263


Actin, Arp2/3, Autophagosome, Autophagy, JMY, LC3, WH2, Actin-Related Protein 2-3 Complex, Actins, Animals, Autophagosomes, Autophagy, Lysosomes, Microtubule-Associated Proteins, Myosins