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Autophagy is a process of self-eating, whereby cytosolic constituents are enclosed by a double-membrane vesicle before delivery to the lysosome for degradation. This is an important process which allows for recycling of nutrients and cellular components and thus plays a critical role in normal cellular homeostasis as well as cell survival during stresses such as starvation or hypoxia. A large number of proteins regulate various stages of autophagy in a complex and still incompletely understood series of events. In this review, we will discuss recent studies which provide a growing body of evidence that actin dynamics and proteins that influence actin nucleation play an important role in the regulation of autophagosome formation and maturation.

Original publication

DOI

10.1007/s00018-016-2224-z

Type

Journal article

Journal

Cell Mol Life Sci

Publication Date

09/2016

Volume

73

Pages

3249 - 3263

Keywords

Actin, Arp2/3, Autophagosome, Autophagy, JMY, LC3, WH2, Actin-Related Protein 2-3 Complex, Actins, Animals, Autophagosomes, Autophagy, Lysosomes, Microtubule-Associated Proteins, Myosins