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The mutagenicity and genotoxicity in bacteria of 2.3THz radiation (THz) produced by a free-electron laser (NovoFEL) were evaluated; exposures were 5, 10, or 15min at average power 1.4W/cm(2). Two Ames mutagenicity test strains of Salmonella typhimurium, TA98 and TA102, were used. For the genotoxicity test, we measured SOS induction in Escherichia coli PQ37. No significant differences were found between exposed and control cells, indicating that THz radiation is neither mutagenic nor genotoxic under these conditions. Nevertheless, a small increase in total cell number of S. typhimurium after 15min exposure, and an increase in β-galactosidase and alkaline phosphatase activities in E.coli PQ37, were observed, indicating some effect of THz radiation on cell metabolism. We also examined the combined effect of 4-NQO (8μM; positive control) and THz exposure (5min) on genotoxicity in E.coli PQ37. Unexpectedly, THz radiation decreased 4-NQO genotoxicity.

Original publication

DOI

10.1016/j.mrgentox.2016.05.005

Type

Journal article

Journal

Mutat Res Genet Toxicol Environ Mutagen

Publication Date

06/2016

Volume

803-804

Pages

34 - 38

Keywords

Ames test, Free electron laser, SOS chromotest, Terahertz radiation, DNA Damage, Escherichia coli, Mutagenicity Tests, Protein Binding, Salmonella typhimurium, beta-Galactosidase