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The E2F1 transcription factor is a recognized regulator of the cell cycle as well as a potent mediator of DNA damage-induced apoptosis and the checkpoint response. Understanding the diverse and seemingly dichotomous functions of E2F1 activity has been the focus of extensive ongoing research. Although the E2F pathway is frequently deregulated in cancer, the contributions of E2F1 itself to tumorigenesis, as a promoter of proliferation or cell death, are far from understood. In this review we aim to provide an update on our current understanding of E2F1, with particular insight into its novel interaction partners and post-translational modifications, as a means to explaining its diverse functional complexity.

Original publication

DOI

10.4161/23723548.2014.970480

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

01/2015

Volume

2

Keywords

DNA damage response, E2F1, apoptosis, cancer, cell cycle, epigenetics