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In this paper, we examine the use of implicit shape representations for nonrigid registration of serial CT liver examinations. Using ground truth in the form of corresponding landmarks manually labeled by a radiotherapist, we carry out an experiment to determine whether nonrigid registration performs better when applied to the original image data or to images constructed from implicit representations of the liver. We compare a variety of standard regularizers (elastic, diffusion, and curvature), similarity measures (sum of squared differences and mutual information), and weighting factors, using three different implicit shape representations: the Euclidean Distance Transform, the Poisson Transform (based on the expected hitting time of a random walk), and a new transform designed to highlight concavities in the shape. ©2008 IEEE.

Original publication




Conference paper

Publication Date



776 - 779