Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Dynamic contrast-enhanced (DCE) MRI is a powerful tool for assessing tumour vasculature and for predicting patient response to therapy. DCE-MRI data can be quantified using pharmacokinetic models, allowing extraction of physiologically meaningful parameters. However, in clinical scans of rectal tumours many voxels within the tumour volume fail to produce valid pharmacokinetic parameters. By performing a sensitivity analysis, we find a high dependence of the model parameters on the pre-contrast relaxation time T10. Estimation of T10 is sensitive to variations in the repetition time and to the effects of patient motion. We develop a new method for incorporating variations in TR into the parameter estimation process and combine it with non-rigid image registration. Our approach offers the potential for a substantial improvement in characterisation of rectal tumours. © 2009 IEEE.

Original publication

DOI

10.1109/ISBI.2009.5192985

Type

Conference paper

Publication Date

17/11/2009

Pages

69 - 72