Variation, Modification, and Reorganization of Broken Chromatin
Humphrey TC., Downs JA., Chambers AL.
© 2016 Elsevier Inc. All rights reserved. DNA damage occurs in the context of chromatin, and, of course, so do recognition and repair of the DNA lesions. It is well established that chromatin composition and dynamics play a central role in the cellular response to DNA damage and, in particular, to double-strand breaks (DSBs). Here, we review recent advances in the contribution of histone posttranslational modifications, histone variants, and chromatin remodeling enzymes to DSB responses.