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Oligonucleotides containing internal triazole-3'-LNA linkages bind to complementary RNA with similar affinity and specificity to unmodified oligonucleotides, and significantly better than oligonucleotides containing triazole alone. In contrast LNA on the 5'-side of the triazole does not stabilise duplexes. Triazole-LNA confers great resistance towards enzymatic degradation relative to LNA alone.

Original publication

DOI

10.1039/c7cc05159j

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

03/08/2017

Volume

53

Pages

8910 - 8913

Keywords

Binding Sites, DNA, Molecular Conformation, Oligonucleotides, RNA, Triazoles