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It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.

Type

Journal article

Journal

Science

Publication Date

24/05/1996

Volume

272

Pages

1187 - 1190

Keywords

Adenomatous Polyposis Coli, Adult, Clone Cells, Colon, DNA Probes, Genotype, Humans, Ileum, In Situ Hybridization, In Situ Hybridization, Fluorescence, Intestinal Mucosa, Karyotyping, Male, Mosaicism, Phenotype, Y Chromosome