Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.

Original publication

DOI

10.1039/c7ob02119d

Type

Journal article

Journal

Org Biomol Chem

Publication Date

19/12/2017

Volume

16

Pages

48 - 52

Keywords

Combinatorial Chemistry Techniques, Crystallography, X-Ray, DNA, Humans, Ligands, Models, Molecular, Molecular Structure, Small Molecule Libraries, Thrombin