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DNA encoded ligands are self-assembled into bivalent complexes and chemically ligated to link their identities. To demonstrate their potential as a combinatorial screening platform for avidity interactions, the optimal bivalent aptamer design (examplar ligands) for human alpha-thrombin is determined in a single round of selection and the DNA scaffold replaced with minimal impact on the final design.

Original publication

DOI

10.1039/c7ob02119d

Type

Journal article

Journal

Org Biomol Chem

Publication Date

19/12/2017

Volume

16

Pages

48 - 52

Keywords

Combinatorial Chemistry Techniques, Crystallography, X-Ray, DNA, Humans, Ligands, Models, Molecular, Molecular Structure, Small Molecule Libraries, Thrombin