Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The retinoblastoma protein (pRb) is considered to be one of the key regulators of cell proliferation. Here we describe our recent findings that linker histone H1.2 is an interaction partner for pRb and impacts upon the genome-wide chromatin binding properties of pRb. Consequently, H1.2 influences transcriptional repression and cell cycle control.

Original publication

DOI

10.1080/23723556.2017.1360977

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2017

Volume

4

Keywords

E2F1, cancer, cell cycle, chromatin, linker histone H1, pRb, transcription