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Electrochemical immunosensors offer much in the potential translation of a lab based sensing capability to a useful "real world" platform. In previous work we have introduced an impedance-derived electrochemical capacitance spectroscopic analysis as supportive of a reagentless means of reporting on analyte target capture at suitably prepared mixed-component redox-active, antibody-modified interfaces. Herein we directly integrate receptive aptamers into a redox charging peptide support in enabling a label-free low picomolar analytical assay for C-reactive protein with a sensitivity that significantly exceeds that attainable with an analogous antibody interface.

Original publication

DOI

10.1021/acs.analchem.7b05374

Type

Journal article

Journal

Anal Chem

Publication Date

06/03/2018

Volume

90

Pages

3005 - 3008

Keywords

Aptamers, Nucleotide, Base Sequence, Biosensing Techniques, C-Reactive Protein, DNA, Electric Capacitance, Electrochemical Techniques, Humans, Oligopeptides