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Two tumour-associated monoclonal antibodies, HMFG1 and HMFG2, were labelled with iodine-123 and used to detect primary and metastatic ovarian, breast, and gastrointestinal neoplasms by external body scintigraphy in twenty patients with advanced disease. Tumours became visible 3 min to 18 h after injection of labelled antibody. The presence of antibody in the tumours was confirmed by autoradiography and immunoperoxidase staining of surgically removed tissues. The mean tumour uptake of radiolabel was 0.6% of the injected amount. These antibodies can therefore localise specifically to tumours and successful imaging can thus be achieved. This method can complement existing diagnostic techniques and also provide a basis for a selective therapeutic approach to malignant disease.

Type

Journal article

Journal

Lancet

Publication Date

06/11/1982

Volume

2

Pages

999 - 1005

Keywords

Adenocarcinoma, Aged, Antibodies, Monoclonal, Antibodies, Neoplasm, Breast Neoplasms, Female, Gastrointestinal Neoplasms, Humans, Immunoenzyme Techniques, Immunoglobulin G, Iodine Radioisotopes, Middle Aged, Ovarian Neoplasms, Radionuclide Imaging