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PURPOSE: To derive lobar ventilation in patients with chronic obstructive pulmonary disease (COPD) using a rapid time-series hyperpolarized xenon-129 (HPX) magnetic resonance imaging (MRI) technique and compare this to ventilation/perfusion single-photon emission computed tomography (V/Q-SPECT), correlating the results with high-resolution computed tomography (CT) and pulmonary function tests (PFTs). MATERIALS AND METHODS: Twelve COPD subjects (GOLD stages I-IV) participated in this study and underwent HPX-MRI, V/Q-SPECT/CT, high-resolution CT, and PFTs. HPX-MRI was performed using a novel time-series spiral k-space sampling approach. Relative percentage ventilations were calculated for individual lobe for comparison to the relative SPECT lobar ventilation and perfusion. The absolute HPX-MRI percentage ventilation in each lobe was compared to the absolute CT percentage emphysema score calculated using a signal threshold method. Pearson's correlation and linear regression tests were performed to compare each imaging modality. RESULTS: Strong correlations were found between the relative lobar percentage ventilation with HPX-MRI and percentage ventilation SPECT (r = 0.644; p 

Original publication




Journal article


Eur Radiol

Publication Date





4058 - 4067


Chronic obstructive pulmonary disease (COPD), Emphysema, Lung, Magnetic resonance imaging (MRI), Single-photon emission computed tomography (SPECT), Aged, Female, Humans, Lung, Magnetic Resonance Imaging, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Reproducibility of Results, Respiration, Respiratory Function Tests, Single Photon Emission Computed Tomography Computed Tomography, Tomography, X-Ray Computed, Xenon Isotopes