Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Low oxygen tension (hypoxia) is a hallmark of cancer that influences cancer cell function, but is also an important component of the tumour microenvironment as it alters the extracellular matrix, modulates the tumour immune response and increases angiogenesis. Here we discuss the regulation and role of hypoxia and its key transcriptional mediators, the hypoxia-inducible factor (HIF) family of transcription factors, in the tumour microenvironment and stromal compartments.

Original publication

DOI

10.1038/ncb3330

Type

Journal article

Journal

Nat Cell Biol

Publication Date

04/2016

Volume

18

Pages

356 - 365

Keywords

Basic Helix-Loop-Helix Transcription Factors, Gene Expression Regulation, Neoplastic, Humans, Hypoxia, Hypoxia-Inducible Factor 1, Models, Biological, Neoplasms, Neovascularization, Pathologic, Signal Transduction, Tumor Microenvironment