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Both Chk 1 and Chk 2 are critically important checkpoint kinases. Chk 1 is an essential gene that is required for normal cell division and Chk 2 has been found to be mutated in an ever-growing list of human malignancies. Our recent studies indicate that both Chk 1 and Chk 2 have roles to play in the physiological stress of hypoxia/reoxygenation. Loss or inhibition of either kinase sensitizes cells to hypoxia/reoxygenation indicating that either or both could represent significant therapeutic targets.

Original publication




Journal article


Cancer Lett

Publication Date





161 - 167


Animals, Cell Hypoxia, Checkpoint Kinase 1, Checkpoint Kinase 2, DNA Damage, G2 Phase, Humans, Neoplasms, Oxygen, Protein Kinases, Protein Serine-Threonine Kinases, Rad51 Recombinase, Signal Transduction