Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Both Chk 1 and Chk 2 are critically important checkpoint kinases. Chk 1 is an essential gene that is required for normal cell division and Chk 2 has been found to be mutated in an ever-growing list of human malignancies. Our recent studies indicate that both Chk 1 and Chk 2 have roles to play in the physiological stress of hypoxia/reoxygenation. Loss or inhibition of either kinase sensitizes cells to hypoxia/reoxygenation indicating that either or both could represent significant therapeutic targets.

Original publication

DOI

10.1016/j.canlet.2005.06.029

Type

Journal article

Journal

Cancer Lett

Publication Date

18/07/2006

Volume

238

Pages

161 - 167

Keywords

Animals, Cell Hypoxia, Checkpoint Kinase 1, Checkpoint Kinase 2, DNA Damage, G2 Phase, Humans, Neoplasms, Oxygen, Protein Kinases, Protein-Serine-Threonine Kinases, Rad51 Recombinase, Signal Transduction