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Hypoxia represents one of the most physiologically relevant stresses, having significant roles in both normal development and malignant progression. Exposure to severe hypoxia leads to the accumulation of p53 which can in turn lead to rapid apoptosis. In contrast to the response to DNA-damaging agents, hypoxia-induced p53 has little or no transcriptional transactivation capabilities and instead seems to function primarily as a transrepressor in order to induce apoptosis.

Original publication




Journal article


Biochem Biophys Res Commun

Publication Date





718 - 725


Animals, Apoptosis, Cell Hypoxia, Cell Line, Tumor, DNA Damage, DNA-Binding Proteins, Gene Expression Regulation, Humans, Hypoxia, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Mice, Neoplasms, Nuclear Proteins, Phosphorylation, Repressor Proteins, Transcription Factors, Transcriptional Activation, Tumor Suppressor Protein p53