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The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.

Original publication

DOI

10.1101/gad.1243304

Type

Journal article

Journal

Genes Dev

Publication Date

15/09/2004

Volume

18

Pages

2183 - 2194

Keywords

Adaptation, Physiological, Animals, Enzymes, Gene Expression Regulation, Developmental, Humans, Hypoxia, Ion Channels, Mitochondria, Neoplasms, Oxygen, Protein Biosynthesis, Reactive Oxygen Species, Reference Values