Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The therapeutic benefit of radiation in the treatment of breast cancer was first noted by Emil Grubbé in January 1896 in Chicago. Less than 60 days after the discovery of X-rays by Wilhelm Conrad Röntgen in Germany in 1895, Grubbé successfully treated an advanced ulcerated breast cancer. The first treatment complications were also noted during these early years of radiotherapy. In 1922, the first case of lung fibrosis after the treatment of breast cancer was described, leading to changes in the radiation techniques used to treat the breast and chest wall. Advances in radiation physics and biology over the past several decades have built upon these early observations to develop more effective and less harmful treatments. This chapter reviews general principles of radiobiology as they apply to breast cancer. © 2011 Springer Science + Business Media.

Original publication





Book title

Breast Surgical Techniques and Interdisciplinary Management

Publication Date



799 - 811