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dishevelled (Dsh) is a member of the segment polarity gene family in Drosophila which plays an important role in the early developmental patterning processes. A human homologue of Dsh (DVL-1) has recently been described. Here, we report the cloning of a second human homologue of Dsh (called DVL-3) by cDNA library screening. The human DVL-3 gene encodes a predicted 716 amino acid protein which exhibits 98% amino acid identity with mouse Dvl-3 and 49% with Drosophila Dsh. DVL-3 was mapped to 3q27. The expression of DVL-3 mRNA was detected in 30 human cell lines and 2 primary cell cultures. DVL-3 mRNA was detected in normal human breast tissues (n = 4) and tumours (n = 25). Statistically, there was no difference in DVL-3 mRNA level between normal breast tissues and tumours. In human colorectal samples, DVL-3 was expressed equally in matched normal tissues, polyps and tumours. The data indicates that DVL-3 is widely expressed in human cells and supports the notion of a new developmental gene family for dishevelled which may have a widespread role in signal transduction.

Original publication




Journal article


Biochem Biophys Res Commun

Publication Date





510 - 516


Adaptor Proteins, Signal Transducing, Amino Acid Sequence, Base Sequence, Breast, Breast Neoplasms, Carcinoma, Cells, Cultured, Chromosome Mapping, Chromosomes, Human, Pair 3, Cloning, Molecular, Colon, Colonic Neoplasms, Colonic Polyps, DNA, Complementary, Dishevelled Proteins, Drosophila Proteins, Gene Expression Regulation, Developmental, Genes, Genes, Developmental, Humans, Molecular Sequence Data, Phosphoproteins, Protein Biosynthesis, Proteins, Tumor Cells, Cultured