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The epidermal growth factor receptor (EGFR)3 is a 170 kD transmembrane tyrosine kinase activated by several ligands. It is required for normal mammary development and lactation and is aberrantly expressed in approximately 40% of breast carcinomas, particularly those with a poor prognostic phenotype. Since EGF receptor levels are elevated in a high proportion of many tumor types its potential as a therapy target is being investigated using the EGF receptor to target toxins, as well as drugs that interfere with signaling and anti-receptor antibodies. These approaches are likely to be most effective when used in the adjuvant situation in combination with chemotherapy.

Original publication




Journal article


J Mammary Gland Biol Neoplasia

Publication Date





131 - 141


Breast, Breast Neoplasms, ErbB Receptors, Female, Gene Expression Regulation, Neoplastic, Humans, Lactation, Ligands