Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Interleukin 4 (IL-4) receptors were detected by a monoclonal antibody on tumor cells of 10 of 29 squamous cell carcinomas and 6 of 17 adenocarcinomas of the lung. None of the small cell carcinomas or carcinoid tumors stained. Parallel sections stained for epidermal growth factor receptors showed that all but 2 of the IL-4 receptor-positive tumors also expressed epidermal growth factor receptors. Positive labeling for IL-4 receptors was also obtained on nonneoplastic bronchial epithelium and on lymphocytes and macrophages infiltrating the tumor stroma. The role of IL-4 and its receptor in normal human lung is unknown, but the expression of IL-4 receptors on particular subtypes of lung tumors suggests that they may have a role in differentiation or proliferation of squamous and adenocarcinomas.

Type

Journal article

Journal

Cancer Res

Publication Date

01/01/1991

Volume

51

Pages

261 - 264

Keywords

Adenocarcinoma, Antibodies, Monoclonal, Carcinoid Tumor, Carcinoma, Small Cell, ErbB Receptors, Humans, Immunoenzyme Techniques, Interleukin-4, Lung, Lung Neoplasms, Receptors, Interleukin-4, Receptors, Mitogen