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Topoisomerase II is a key target of many anticancer drugs used to treat lung cancer. We measured the expression of topoisomerase IIα and β mRNA's and also the levels of cellular topoisomerase IIα and β protein and concluded that topoisomerase IIα levels are important in cellular resistance to the topoisomerase II inhibitors examined. This can be clearly seen in pairs of matched cell lines. However, when looking at a panel of cell lines with a range of histological types the importance of the enzyme can be masked by other cellular characteristics such as repair and detoxification mechanisms.

Type

Journal article

Journal

Anticancer Research

Publication Date

01/07/1996

Volume

16

Pages

1603 - 1610