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Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidectomized patient responded to aminoglutethimide for 14 months. Oestrone and oestradiol were suppressed by AG in all patients, but not to the levels achieved by orchidectomy. AG produced substantial further oestrogen suppression in the orchidectomized patient and should only be used after orchidectomy.

Type

Journal article

Journal

Br J Cancer

Publication Date

10/1986

Volume

54

Pages

657 - 660

Keywords

Aminoglutethimide, Breast Neoplasms, Drug Therapy, Combination, Estradiol, Estrone, Humans, Hydrocortisone, Lung Neoplasms, Male, Orchiectomy, Tamoxifen