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A sample of 125 individuals from 37 British cystic fibrosis (CF) families with at least one living affected child were typed with probes for restriction fragment length polymorphisms (RFLPs) known to be linked to the CF gene. These probes were MetD, MetH, pJ3.11 and 7C22. Using this combination of probes, 30 out of the 37 families were sufficiently informative to enable prenatal diagnosis of the disease. Linkage analysis has also proved to be useful in excluding CF in two cases where diagnosis of the disease was equivocal in the sibling of an affected child.

Type

Journal article

Journal

Hum Genet

Publication Date

05/1988

Volume

79

Pages

76 - 79

Keywords

Alleles, Cystic Fibrosis, DNA, Female, Gene Frequency, Genetic Linkage, Genetic Markers, Genetic Testing, Humans, Male, Pedigree, Polymorphism, Restriction Fragment Length