Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Genetic analysis of the CF locus in the British Caucasian population has been extended using six DNA probes detecting nine polymorphic loci. Data are presented on (1) diagnostic usefulness of probes, and (2) allele frequencies for each probe in this population. For the probes pXV2C and KM19 (those closest to the CF locus) allele frequencies are further subdivided into male and female derived chromosomes 7. The allele frequencies for both probes on non-CF bearing chromosomes 7, but not on CF carrying chromosomes 7, are substantially different in males and females. Combined haplotypes for pXV2C and KM19 show that, as has been observed in other northern European populations, almost 90% of CF chromosomes in this population carry the pXV2C/KM19, 1/2 (2.1 kb/6.6 kb) haplo-type.


Journal article


J Med Genet

Publication Date





39 - 41


Alleles, Chromosomes, Human, Pair 7, Cystic Fibrosis, DNA Probes, Female, Gene Frequency, Genetic Markers, Humans, Male, United Kingdom