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Two studies were carried out (A and B) in order to assess the effectiveness of ifosfamide administered with mesna (IFO/M) in the treatment of small cell lung cancer. The first study (A) was a cross-over study; the second (B) was a randomized trial, and in B IFO/M was evaluated earlier in the course of the disease. IFO/M given be infusion is effective as second-line therapy and can be administered with other cytotoxics at the doses reported here earlier in the course of the disease. The complete remission rates were high.


Journal article


Cancer Chemother Pharmacol

Publication Date



18 Suppl 2


Antineoplastic Combined Chemotherapy Protocols, Carcinoma, Small Cell, Drug Evaluation, Humans, Ifosfamide, Infusions, Intravenous, Lung Neoplasms, Mercaptoethanol, Mesna