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Patients with resectable oesophageal adenocarcinoma (OAC) recommended for neoadjuvant chemotherapy. Additionally, the VISTA trial focuses on target populations with specific HLA type for each Phase as described below:

Phase I Safety Lead-in: HLA A*02:01

Phase II Randomised trial: At least one or more of HLA A*02:01HLA B*07:02 or HLA B*40:01

(Detailed eligibility criteria mentioned below)

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