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The Radiation Biophysics Facility develops and supports a unique range of radiation resources and techniques along with providing associated expertise.

R biophysics 2

The Radiation Biophysics facilities range from those used for basic cell irradiations (including techniques capable of manipulating radiation fields on the sub-cellular micron scale) through to supporting and developing a SARRP image guided pre-clinical x-ray irradiator and includes developing techniques for dosimetry on clinical machines.

One of the main research interests includes investigating how and why ionising radiation initiates a diverse range of biological responses. We are also interested in how this correlates to differences in the temporal and spatial pattern of energy deposition events on the scale of DNA, cells and tissues associated with different radiation qualities of ionizing radiation. Mechanisms are thus formulated which are interpreted in the context of risk associated with exposure or which can potentially be exploited in radiotherapy.

Radiation Biophysics is available to assist with all aspects of radiation delivery and dosimetry. We are able to deliver a wide range of radiation energies and qualities using our existing facilities, as well as to perform custom dosimetry both on and off site.  We can also design novel experiments and equipment to suit your requirements.

 To discuss your requirements, please contact Mark Hill.

SeLECTED PUBLICATIONS

F. Verhaegen, L. Dubois, S. Gianolini, M.A. Hill, C.P. Karger, K. Lauber, K. M. Prise, D. Sarrut, D. Thorwarth, C. Vanhove, B. Vojnovic, R. Weersink, J. J. Wilkens, D. Georg, Technology for Precision Small Animal Radiotherapy Research: optimal use and challenges, Radiotherapy and Oncology. 126, 471-478 (2018)  [PMID: 29269093]

M. Durante, E. Brauer-Krish, M.A. Hill. Faster and safer? FLASH ultra-high dose rate in radiotherapy. Br J Radiol. 91, 20170628 (2018) [PMID: 29172684]

R. Carter, C. Nickson, J.M. Thompson, A. Kacperek, M.A. Hill, J. Parsons, Complex DNA damage induced by high-LET α-particles and protons triggers a specific cellular DNA damage response. Int J Radiat Oncol Biol Phys. 100, 776-784 (2018) [PMID: 29413288]

P. Abnave, E. Aboukhatwa, N. Kosake, J.M. Thompson, M.A. Hill and A.A. Aboobaker, Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians. Development, 144, 3440-3453 (2017) [PMID: 28893948]

M.A. Hill, J.M. Thompson, A. Kavanagh, I.D.C. Tullis, R.G. Newman, J. Prentice, J. Beech, S. Gilchrist, S. Smart, E. Fokas, B. Vojnovic The Development of Technology for Effective Respiratory-Gated Irradiation Using an Image-Guided Small Animal Irradiator. Radiat Res. 188, 247-263 (2017) [PMID: 28715250]

M.A. Hill, P. O’Neill and W.G. McKenna, Comments on potential health effects of MRI-induced DNA lesions: quality is more important to consider than quantity. Eur Heart J Cardiovasc Imaging. 17, 1230-1238 (2016) [PMID: 27550664]