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Contact information


eric.oneill@oncology.ox.ac.uk


+44 (0)1865 617321

CONNECT WITH ME

Research groups

Eric O'Neill

Professor of Cell and Molecular Biology

Research Summary

Our research aims to understand the cell and molecular biology behind frequent tumour mutations and how they influence cancer onset and/or therapy. 

Members of the group span the whole basic-to-translational research spectrum, with backgrounds in clinical medicine, mathematics, biochemistry, and biomedical sciences. Employing both wet-lab and computational methods, we investigate crucial aspects of (pancreatic) cancer development and therapy. Ongoing projects in the lab broadly cover two key areas:

- Mechanotransduction and signal integration from the extracellular matrix to the nucleus, with a focus on Rassf1a,
- Immuno-oncology and immunotherapy of pancreatic and oesophageal cancers, with a focus on T cells, NK cells, and macrophages.

More recently, we have begun investigating other aspects of cancer, including the complex interplay between cancer and mental health conditions, and the mechanistic modelling of multitargeted therapeutics.

COLLABORATORS

Academic

Clinical

Industry

GROUP MEMBERS

Current lab members

Keaton Jones, Academic Clinical Lecturer
Tess Stanly, Postdoc
Alice Evans, DPhil student (iCASE)
Ben Futcher, DPhil student (Oncology)
Constantinos Demetriou, DPhil student (Oncology)
Alexander Hasson, DPhil student (iCASE)
Giampiero Valenzano, CRTF (Cancer Science)
Elsita Jungkurth, DPhil student (Oncology)
Shannon Russell, DPhil student (Oncology)
Ashley Newton, DPhil student (Oncology)
Gift Gwawawa, DPhil student (Oncology)
Azmaeen Zarif, MSc student (Oncology)
Mohammed Ahmed, Research fellow

Past lab members

Simei Go, Postdoc
Cameron Lang, DPhil student
Haonan Xu, DPhil student
Sophie Hughes, DPhil student
Daniel Hughes, CRTF