Adrian L Harris
MB.ChB, BSc Hons, MA, DPhil, MD [Hon], FRCP, FMedSci, DSc[Med]
Emeritus Professor of Medical Oncology
- Professorial Fellow, St Hugh's College
- Consultant Medical Oncologist, Oxford University Hospitals NHS Trust
Biography
From 1989-2017, Adrian L Harris was the first Professor of Medical Oncology at Oxford University and developed the Department. He has been Cancer Research UK Professor of Medical Oncology at the University of Oxford since 1989 and directed the Cancer Research UK Molecular Oncology Laboratories at the Weatherall Institute of Molecular Medicine (WIMM) until 2017. He was a Consultant Medical Oncologist and is a Professorial Fellow of St Hugh’s College Oxford. Prof. Harris was Editor-in-Chief of the British Journal of Cancer for 15 years, and on the Editorial Board of Cancer Cell. He is a Senior Investigator in the National Institute of Health Research and a founder Fellow of the Academy of Medical Sciences. He was a Trustee and Chairman of the Science Strategy Committee for Breast Cancer NOW.
Prof. Harris is a ‘Highly Cited Researcher’, ranking among the top 1% most cited for their subject field and year of publication. He has published over 500 articles and there are over 196,000 citations to them, Google Scholar h index 213.
Prof. Harris received a Platinum Merit Award from the National Health Service for the last 15 years, given to the 200 most outstanding consultants for all specialities.
Prof. Harris trained in Medicine and Biochemistry at Liverpool University, did a DPhil at Oxford University then trained at the Royal Marsden Hospital in Medical Oncology. He was appointed Professor of Clinical Oncology at Newcastle-upon-Tyne in 1982. He has managed breast cancer patients for over 35 years. He continues run research programmes in Oxford University.
His major laboratory interests involve the role of hypoxia in breast tumour biology, tumour angiogenesis, the metabolic response to hypoxia, and hypoxia-induced cell death. He has conducted many predictive and prognostic studies and early exploratory phase trials in new drug development. He used molecular pathology and biomarkers to develop new agents with pharmacodynamic monitoring for proof of target engagement.
Key publications
Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis.
Journal article
Dragovic RA. et al, (2011), Nanomedicine, 7, 780 - 788
Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma.
Journal article
Lawrie CH. et al, (2008), Br J Haematol, 141, 672 - 675
Breast cancer classification and prognosis based on gene expression profiles from a population-based study.
Journal article
Sotiriou C. et al, (2003), Proc Natl Acad Sci U S A, 100, 10393 - 10398
Hypoxia--a key regulatory factor in tumour growth.
Journal article
Harris AL., (2002), Nat Rev Cancer, 2, 38 - 47
Hypoxia-inducible expression of tumor-associated carbonic anhydrases.
Journal article
Wykoff CC. et al, (2000), Cancer Res, 60, 7075 - 7083
The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages.
Journal article
Talks KL. et al, (2000), Am J Pathol, 157, 411 - 421
Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma.
Journal article
Leek RD. et al, (1996), Cancer Res, 56, 4625 - 4629
Recent publications
Distinct regulatory elements of SLC6A14 expression contribute to modification of cystic fibrosis phenotypes.
Journal article
Esmaeili M. et al, (2026), Hum Genet, 145
Molecular phenotypes in early gallbladder and liver disease in the CFTR-/- sheep highlight aspects of cystic fibrosis-relevant hepatobiliary disease.
Journal article
Meckler F. et al, (2025), Physiol Genomics, 57, 682 - 694
Amyloid-β disrupts APP-regulated protein aggregation and dissociation from recycling endosomal membranes.
Journal article
Singh PJ. et al, (2025), EMBO J, 44, 4443 - 4472
CFTR Gene Regulation in Human Pancreatic Duct, Bile Duct and Sweat Gland Epithelial Cells.
Journal article
Umrigar A. et al, (2025), J Cell Mol Med, 29
A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding.
Journal article
Wang C-Y. et al, (2025), Commun Med (Lond), 5
Cellular imbalance in proximal and distal lung of CFTR-/- sheep in utero and at birth.
Journal article
Leir S-H. et al, (2025), Mol Med, 31
Low cytoplasmic NUB1 protein exerts hypoxic cell death with poorer prognosis in oestrogen receptor negative breast cancer patients.
Journal article
Tan K-L. et al, (2024), Transl Oncol, 49
Autophagy Blockage Up-Regulates HLA-Class-I Molecule Expression in Lung Cancer and Enhances Anti-PD-L1 Immunotherapy Efficacy.
Journal article
Xanthopoulou E. et al, (2024), Cancers (Basel), 16
Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
Stellate cells are in utero markers of pancreatic disease in cystic fibrosis.
Journal article
Leir S-H. et al, (2024), Mol Med, 30
Functional genomics of the human epididymis: Further characterization of efferent ducts and model systems by single-cell RNA sequencing analysis.
Journal article
Leir S-H. et al, (2024), Andrology, 12, 991 - 1000
A promoter-dependent upstream activator augments CFTR expression in diverse epithelial cell types.
Journal article
Coatti GC. et al, (2024), Biochim Biophys Acta Gene Regul Mech, 1867
Investigating adverse genomic and regulatory changes caused by replacement of the full-length CFTR cDNA using Cas9 and AAV.
Journal article
Vaidyanathan S. et al, (2024), Mol Ther Nucleic Acids, 35
Cone photoreceptor phosphodiesterase PDE6H inhibition regulates cancer cell growth and metabolism, replicating the dark retina response.
Journal article
Yalaz C. et al, (2024), Cancer Metab, 12
A systems-based approach to uterine fibroids identifies differential splicing associated with abnormal uterine bleeding
Preprint
Wang CY. et al, (2024)
The impact of genomic distance on enhancer-promoter interactions at the CFTR locus.
Journal article
Kerschner JL. et al, (2024), J Cell Mol Med, 28
GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner.
Journal article
Wang Z. et al, (2023), Cancer Res, 83, 3400 - 3413
Data from GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner
Other
Wang Z. et al, (2023)
Data from GTP Cyclohydrolase Drives Breast Cancer Development and Promotes EMT in an Enzyme-Independent Manner
Other
Wang Z. et al, (2023)
A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis in Drosophila secondary cells.
Journal article
Wells A. et al, (2023), PLoS Genet, 19
Targeting mitochondrial oxidative phosphorylation: lessons, advantages, and opportunities.
Journal article
Machado ND. et al, (2023), Br J Cancer, 129, 897 - 899
Metabolic Symbiosis between Oxygenated and Hypoxic Tumour Cells: An Agent-based Modelling Study
Preprint
Jayathilake PG. et al, (2023)
Cellular heterogeneity in the 16HBE14o- airway epithelial line impacts biological readouts.
Journal article
Kerschner JL. et al, (2023), Physiol Rep, 11
An ectopic enhancer restores CFTR expression through de novo chromatin looping.
Journal article
Kerschner JL. et al, (2023), Gene Ther, 30, 478 - 486
Transcriptomic analysis of lung development in wildtype and CFTR-/- sheep suggests an early inflammatory signature in the CF distal lung.
Journal article
Kerschner JL. et al, (2023), Funct Integr Genomics, 23
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
Journal article
Lord SR. and Harris AL., (2023), Br J Cancer, 128, 958 - 966
Predicting Breast Cancer Events in Ductal Carcinoma In Situ (DCIS) Using Generative Adversarial Network Augmented Deep Learning Model.
Journal article
Ghose S. et al, (2023), Cancers (Basel), 15
Accessory ESCRT-III proteins are conserved and selective regulators of Rab11a-exosome formation.
Journal article
Marie PP. et al, (2023), J Extracell Vesicles, 12
75th anniversary of the British Journal of Cancer
Journal article
Harris AL., (2023), British Journal of Cancer, 128
Dual SMAD inhibition enhances the longevity of human epididymis epithelial cells.
Journal article
Coatti GC. et al, (2023), Cell Tissue Res, 391, 409 - 417
Metabolic Reprogramming in Colon Cancer Cells Persistently Infected with Newcastle Disease Virus.
Journal article
Yu T. et al, (2023), Cancers (Basel), 15
Early developmental phenotypes in the cystic fibrosis sheep model.
Journal article
Van Wettere AJ. et al, (2023), FASEB Bioadv, 5, 13 - 26
Stress-induced Rab11a-exosomes induce AREG-mediated cetuximab resistance in colorectal cancer
Preprint
Mason J. et al, (2023)
A Rab6 to Rab11 transition is required for dense-core granule and exosome biogenesis inDrosophilasecondary cells
Preprint
Wells A. et al, (2023)
Enhancement of airway epithelial cell differentiation by pulmonary endothelial cell co-culture.
Journal article
Burkhanova U. et al, (2022), Stem Cell Res, 65
Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1α Hypoxia Sensor.
Journal article
Golinska MA. et al, (2022), Cells, 11
Tumor Infiltrating Lymphocytes in Multi-National Cohorts of Ductal Carcinoma In Situ (DCIS) of Breast.
Journal article
Badve SS. et al, (2022), Cancers (Basel), 14
Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation.
Journal article
Zois CE. et al, (2022), Cell Death Dis, 13
Krüppel-Like Factor 5 Regulates CFTR Expression Through Repression by Maintaining Chromatin Architecture Coupled with Direct Enhancer Activation.
Journal article
Paranjapye A. et al, (2022), J Mol Biol, 434
Radiogenomic analysis of primary breast cancer reveals [18F]-fluorodeoxglucose dynamic flux-constants are positively associated with immune pathways and outperform static uptake measures in associating with glucose metabolism.
Journal article
Ralli GP. et al, (2022), Breast Cancer Res, 24
Cross-talk between enhancers, structural elements and activating transcription factors maintains the 3D architecture and expression of the CFTR gene.
Journal article
Yin S. et al, (2022), Genomics, 114

