Websites
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Department of Cellular and Molecular Medicine
University of Copenhagen
Colleges
Andrew Blackford
PhD
Associate Professor & CRUK Senior Fellow
Andrew Blackford is an associate professor and group leader in the Department of Oncology, based at the MRC Weatherall Institute of Molecular Medicine. His group studies the signalling mechanisms cells use to respond to DNA damage and why defects in these pathways cause human diseases such as cancer.
After obtaining his PhD in the School of Cancer Sciences at the University of Birmingham in 2008, he undertook postdoctoral positions with Wojciech Niedzwiedz at the University of Oxford in 2009 and Steve Jackson in the Wellcome Trust/CRUK Gurdon Institute at the University of Cambridge in 2012. He established his lab in 2016 with the support of a Cancer Research UK Career Development Fellowship, and was awarded a Senior Cancer Research Fellowship from Cancer Research UK in 2023 to continue his research.
In 2024, he was awarded a Novo Nordisk Foundation Hallas-Møller Ascending Investigator fellowship to establish a new lab in the Center for Chromosome Stability in the Department of Cellular and Molecular Medicine at the University of Copenhagen.
GROUP MEMBERS
Kaima Tsukada, Postdoctoral Researcher
Liudmyla Lototska, Postdoctoral Researcher
Ipek Ilgin Gönenc, Postdoctoral Researcher
Julius Bannister, DPhil Student
Jan Bisenberger, Laboratory Assistant
Recent publications
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BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.
Journal article
Tsukada K. et al, (2024), Mol Cell
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Targeting DNA damage response pathways in cancer
Journal article
Groelly FJ. et al, (2022), Nature Reviews Cancer
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Mitotic DNA synthesis is caused by transcription-replication conflicts in BRCA2-deficient cells.
Journal article
Groelly FJ. et al, (2022), Mol Cell
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The CIP2A-TOPBP1 complex safeguards chromosomal stability during mitosis.
Journal article
De Marco Zompit M. et al, (2022), Nat Commun, 13
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Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.
Journal article
Hodson C. et al, (2022), Proc Natl Acad Sci U S A, 119
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The Bloom syndrome complex senses RPA-coated single-stranded DNA to restart stalled replication forks.
Journal article
Shorrocks A-MK. et al, (2021), Nat Commun, 12
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CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.
Journal article
Ochi T. et al, (2020), Structure
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How Cells Respond to DNA Breaks in Mitosis.
Journal article
Blackford AN. and Stucki M., (2020), Trends Biochem Sci
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Treacle controls the nucleolar response to rDNA breaks via TOPBP1 recruitment and ATR activation.
Journal article
Mooser C. et al, (2020), Nat Commun, 11
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MDC1 Interacts with TOPBP1 to Maintain Chromosomal Stability during Mitosis.
Journal article
Leimbacher P-A. et al, (2019), Mol Cell, 74, 571 - 583.e8