Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Research groups

Ejung Moon

PhD


Group Leader in Radiation Biology and the Tumour Microenvironment

Research Interest

In Moon lab, we focus on determining how hypoxia promotes tumour progression such as invasion, metastasis, and metabolism through key pathways involving MAFF protein.

The regulation of MAFF protein, a family of transcription factors, has been implicated in the transactivation of antioxidant response genes. Our work demonstrated that the level of small MAFF protein expression is critical to the regulation of gene induction or repression, indicating that stresses like hypoxia act like a rheostat in regard to the formation of MAFF homodimer and heterodimer formation, leading to transactivation or gene repression. Biologically, we found that the MAFF protein is a major regulator of tumour cell invasion and metastasis under hypoxia, and impact the radiation response of cells though controlling antioxidant gene transcription. Moon lab will focus on how MAFF itself, or along with its binding proteins, interplays to alter tumour metabolism and radiation damage under hypoxic conditions. 

Biography

Dr. Moon received her PhD degree from Duke University, USA. She was trained by Dr. Mark W. Dewhirst to focus on the effect of hypoxia-inducible factor (HIF) on tumour reoxygenation after mild hyperthermia. During the training, she was awarded a predoctoral fellowship from Breast Cancer Research Program (BCRP) of Department of Defense (DoD), USA. Then she joined Dr. Amato Giaccia’s lab at Stanford University, USA, to study hypoxia regulation of MAFF protein and its role in tumour cell invasion and radiation responses. Her current research interests are radiation responses and metabolic changes under hypoxia. 

Group Members

Nuria Vilaplana Lopera, PhD, Postdoctoral Researcher

Jiyoung Kim, Research Assistant