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Enric Domingo

BSc, MSc, PhD


Postdoc in bioinformatics

RESEARCH SUMMARY

My work has always been focused on colorectal cancer and translational research, with a slow transition from the wet lab to computer-based research. My main goal is the identification of biomarkers that could be implemented clinically to improve healthcare. Accordingly, along my career I have identified highly relevant biomarkers in colorectal cancer (eg BRAF mutation to exclude germline predisposition; POLE mutation for good prognosis; PIK3CA mutation for benefit with aspirin). 

My research is strongly focused on molecular profiling of human tumours. To that end, I apply a wide range of bioinformatical tools to multi-omic data (eg DNA sequencing, DNA methylation, RNA expression, protein expression) from highly selected patients of clinical trials or hospital-based cohorts. Several of them are from the S:CORT programme, a stratified medicine consortium looking for biomarkers of response to oxaliplatin, radiotherapy, prognosis and novel biological therapies. I lead my own research lines (eg germline variants, some specific biomarker candidates, site of metastasis) and have tight collaborations with the whole S:CORT team and other researchers nationally and internationally.

BIOGRAPHY

I received a BSc in Biology (Autonomous University of Barcelona) and a MSc and PhD in Genetics (Vall d’Hebron Research Institute, Barcelona). I have also been a visiting fellow in INSERM (Paris) and postdoc in the London Research Institute (now The Francis Crick Institute) and the Wellcome Trust Centre for Human Genetics (Oxford).

Key publications

Recent publications

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