Enric Domingo

BSc, MSc, PhD

SENIOR RESEARCHER IN BIOINFORMATICS

Molecular pathology, Biomarkers, Colorectal cancer

RESEARCH SUMMARY

My work has always been focused on colorectal cancer and translational research, initially working in the wet lab and then moving onto computer-based research. My main goal is the identification of biomarkers that could be implemented clinically to improve healthcare. Accordingly, along my career I have reported highly relevant biomarkers in colorectal cancer (eg BRAF mutation to exclude germline predisposition; POLE mutation & imCMS for prognosis; PIK3CA mutation for benefit with aspirin; RSS signature & imCMS for response to radiotherapy).

My research is strongly focused on molecular profiling of human tumours. To that end, I apply a wide range of bioinformatical tools to interrogate multi-omic data (eg DNA sequencing, DNA methylation, RNA expression, protein expression) from clinical trials or other cohorts. As such, I lead bioinformatical analyses for S:CORT (a consortium looking for stratifiers for oxaliplatin, radiotherapy, prognosis and novel biological therapies) and transSCOT (translational analyses for the large clinical trial SCOT). I also lead my own research lines (eg some specific biomarker candidates, site of metastasis) and have tight collaborations with colleagues nationally and internationally.

BIOGRAPHY

I received a BSc in Biology (Autonomous University of Barcelona) and a MSc and PhD in Genetics (Vall d’Hebron Research Institute, Barcelona). I have also been a visiting fellow in INSERM (Paris) and postdoc in the CRUK London Research Institute (later on incorporated into The Francis Crick Institute) and the Centre for Human Genetics (Oxford).

I have over 80 publications with a mean impact factor of 20 and over 12,000 citations, including 13 first author publications and 4 as last and/or corresponding author.

I am also lecturer for MSc programmes in the Department of Oncology (Applied Cancer Sciences, Radiobiology) and the Centre for Human Genetics (Genomic Medicine).