I investigate how tumours survive in conditions which include low oxygen (hypoxia). The goal is to target the hypoxic parts of tumours to improve cancer therapy.

Biography

Ester completed her PhD at the School for Cancer Sciences, University of Birmingham then accepted a post as a postdoctoral fellow within the Molecular Oncology Group at the University of Cambridge School of Clinical Medicine before moving to the USA to join the Department of Radiation Oncology at Stanford University, first as a postdoctoral fellow then a research associate.

She joined the Oxford Institute in 2007 as a CRUK junior group leader.

GROUP MEMBERS

Sam Bader, DPhil Student

Ming-Shih Hwang, Postdoctoral Researcher

Katarzyna Leszczynska, Postdoctoral Researcher

Tiffany Ma, DPhil student

Anna Mandel, MRes student

Natalie Ng, DPhil Student

Shaliny Ramachandran, Postdoctoral Researcher

Karen Sayal, Clinical Research Fellow

GROUP ALUMNI & NEXT DESTINATIONS

Alhasan Al-Habib (2017), MSc Student - PhD student, Cambridge University, UK

Karin Purshouse (2016-17), ACF - ACF, Oxford University Hospitals Trust, UK

Greg Dobrynin (2014-17), Postdoctoral Researcher - Senior Scientist, Immunocore Ltd, UK

Iosifina Foskolou (2012-16), DPhil Student - Postdoctoral Researcher, Cambridge University, UK

Liam O'Connor (2012-16), DPhil Student - Patent lawyer, UK

Cindy Korner (2010-15), MSc/DPhil Student - Postdoctoral Researcher, Karolinska Institute, Sweden

Selva Anbalagan (2009-14), MSc/DPhil Student - Postdoctoral Researcher, ICR, London, UK

Monica Olcina (2009-14), MSc/DPhil Student - Postdoctoral Researcher, Stanford University, US

Isabel Pires (2007-12), Postdoctoral Researcher - Lecturer, University of Hull, UK

Recent publications

Hypoxia-activated small molecule-induced gene expression.
Journal article

Collins SL. et al, (2018), ACS Chem Biol
Replication Stress Drives Constitutive Activation of the DNA Damage Response and Radioresistance in Glioblastoma Stem-like Cells.
Journal article

Carruthers RD. et al, (2018), Cancer Res, 78, 5060 - 5071
Hypoxia activated small molecule induced gene expression
Journal article

Collins S. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256
Hypoxia-activated prodrugs of the KDAC inhibitor panobinostat
Conference paper

Calder E. et al, (2018), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 256
BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.
Journal article

Jennings LE. et al, (2018), Bioorg Med Chem, 26, 2937 - 2957

More publications