Contact information
ester.hammond@oncology.ox.ac.uk
+44 (0)1865 617320
Follow the Hammond Lab on Bluesky - @Hammond-lab.bsky.social
Research groups
Research Theme
Tumour Microenvironment (Lead Principal Investigator)
Websites
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redOx⇌KCL
Collaborative interdisciplinary programme funded by the EPSRC
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RadNet seminar by Prof. Hammond
Watch on YouTube
Colleges
Ester Hammond
Professor of Molecular Cancer Biology
- TME Research Theme lead, Department of Oncology
- Director of the Oxford-MRC Doctoral Training Partnership
Research Summary
I investigate how tumours survive in conditions which include low oxygen (hypoxia). The goal is to target the hypoxic parts of tumours to improve cancer therapy.
Biography
Ester completed her PhD at the School for Cancer Sciences, University of Birmingham then accepted a post as a postdoctoral fellow within the Molecular Oncology Group at the University of Cambridge School of Clinical Medicine before moving to the USA to join the Department of Radiation Oncology at Stanford University, first as a postdoctoral fellow then a research associate. She joined the Department in 2007.
GROUP MEMBERS
RECENT GROUP ALUMNI & NEXT DESTINATIONS
Louise Martin (2023-2024) Research Assistant - DPhil student University of Oxford, UK
Çağla Tosun (2020-2024) DPhil student/Postdoctoral Researcher - Postdoctoral Researcher University of Nottingham, UK
Tiffany Ma (2018-23), DPhil student/Postdoctoral Researcher - Precision Immunomics Scientist Infinitopes, UK
Sam Bader (2016-21), DPhil student - Scientist, Totus Medicines, USA
Charlotte Simpson (2020-2021) MRes student - PhD student, University of Cambridge, UK
Natalie Ng, (2016–21), DPhil student - Scientist, Oxford Biomedica, UK
Anna Mandel, (2018-20), MRes student - PhD student, University of Toronto, Canada
Ania Skwarska, (2019-20) Postdoctoral Researcher - Postdoctoral Researcher Medical University of Bialystok, Poland
Elizabeth Bowler, (2019 -20) Postdoctoral Researcher - Postdoctoral Researcher University of Bath
Recent publications
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SRSF2 overexpression induces transcription-/replication-dependent DNA double-strand breaks and interferes with DNA repair pathways to promote lung tumor progression.
Khalife M. et al, (2025), NAR Cancer, 7
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LnDOTA Releasing Probes for Luminescence and Magnetic Resonance Imaging.
Foster CA. et al, (2025), Inorg Chem
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Hypoxia-activated fluorescent probes as markers of oxygen levels in plant cells and tissues
Perri M. et al, (2025)
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Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.
Goncalves T. et al, (2025), Nucleic Acids Res, 53
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Elevated reactive oxygen species can drive the alternative lengthening of telomeres pathway in ATRX-null cancers.
Goncalves T. et al, (2025), Nucleic Acids Res, 53
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Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation.
Estephan H. et al, (2025), EMBO J
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ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1.
Kambe G. et al, (2024), Biochem Biophys Res Commun, 733
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The activity of therapeutic molecular cluster Ag5 is dependent on oxygen level and HIF-1 mediated signalling.
Twigger SA. et al, (2024), Redox Biol, 76