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Contact information


geoffrey.higgins@oncology.ox.ac.uk


+44 (0)1865 617311

Research groups

Research Theme

Tumour Microenvironment (Lead Principal Investigator)

COLLABORATORS

Chris Schofield, Department of Chemistry, University of Oxford
Ester Hammond, Department of Oncology, University of Oxford
Monica Olcina, Department of Oncology, University of Oxford
Kevin Harrington, Institute of Cancer Research, London

Geoff Higgins

MBChB, MRCP, FRCR, DPhil

Associate Professor

  • Malcolm & Margaret Howat Associate Professor of Clinical Oncology
  • Honorary Consultant Clinical Oncologist, Oxford University Hospitals NHS Trust

Research Summary

Our group’s aim is to develop strategies to increase the efficacy of radiotherapy treatment. This work often involves repurposing existing compounds, or developing new treatments, that can be effectively combined with radiotherapy. Where possible, we seek to translate our laboratory findings into clinical trials utilising functional imaging and genomic data to provide signals of pharmacodynamic efficacy. 

Biography

Geoff Higgins is the Malcolm & Margaret Howat Associate Professor in Clinical Oncology.

He obtained degrees in pharmacology (1997) and medicine (2000) from Edinburgh University and undertook specialist training in Clinical Oncology at the Edinburgh Cancer Centre. He subsequently moved to Oxford and was awarded a Royal College of Radiologists/CRUK Clinical Research Fellowship leading to a DPhil in 2010. Geoff subsequently obtained his Clinician Scientist and Advanced Clinician Scientist Fellowships from Cancer Research UK.

His research includes laboratory and clinical research aiming to improve the efficacy of radiotherapy treatment. He is currently the Chief Investigator of two clinical trials and is joint-lead investigator of the CRUK National Cancer Imaging Translational Accelerator.

CURRENT GROUP MEMBERS

Laboratory Research:

Gonzalo Rodriguez-Berriguete, Senior Postdoctoral Researcher

Celia Gotorbe, Postdoctoral Researcher

Puru Thambiayah, DPhil student

Nicole Machado, DPhil Student

Wing Yu Lee, MRes Student

Clinical Research:

Robert Rulach, Consultant Radiation Oncologist

Daniel McGowan, Postdoctoral Researcher

Kelley Ferreira, NPL Physicist and DPhil Student

Daniel Murray, Senior radiotherapy dosimetrist and DPhil student

GROUP ALUMNI & NEXT DESTINATIONS

Giovanna Granata (DPhil Student 2016-2020) – Postdoctoral Researcher, Amsterdam UMC

James Coates (DPhil Student 2015-2019) – Postdoctoral Researcher, Harvard University

Kate Herbert (Postdoctoral Researcher 2015-2019) – Postdoctoral Researcher, University of Glasgow

Michael Skwarski (Clinical Research Fellow 2016-2019) – Consultant Clinical Oncologist, Guy’s Hospital, London

Tom Ashton (Postdoctoral Researcher 2011-2017) – Senior Scientist, Adaptimmune Therapeutics

Daniel McGowan (DPhil Student 2013-2016) – NIHR Clinical Lecturer and Medical Physicist, Oxford

Giacomo Pirovano (DPhil student 2012-2015) – Postdoctoral Researcher, Memorial Sloan Kettering Cancer Centre, New York

Gagan Tiwana (DPhil Student 2012-2015) – Senior Scientist, Horizon Discovery