Kerry Fisher
PhD
Associate Professor
Tumour microenvironment, primary tissue samples and translational science
My research is focused on the tumour microenvironment, notably addressing abnormal metabolism and dysfunctional immune activity. The structure and composition of tumour stroma can influence disease progression and, crucially, the performance of therapeutic drugs. Conventional laboratory models do not fully recapitulate the complexity of the tumour microenvironment and our research team makes extensive use of fresh biopsy material from patients. We have expanded this work to form a live tissue facility for the benefit of the department and our collaborators.
Translating new therapies to the clinic often involves working with industry, either established companies or new spin-out biotechs from the University. Over the last 20 years I have been involved in many industrial collaborations in one form or another, helping to manage the development of new treatments from the initial innovation through to science-led clinical trials.
Recent publications
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T cell engagers: expanding horizons in oncology and beyond.
Journal article
Albayrak G. et al, (2025), Br J Cancer, 133, 1241 - 1249
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Deregulation of HLA-I in cancer and its central importance for immunotherapy.
Journal article
Hazini A. et al, (2021), J Immunother Cancer, 9
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Polymer stealthing and mucin-1 retargeting for enhanced pharmacokinetics of an oncolytic vaccinia virus.
Journal article
Hill C. et al, (2021), Mol Ther Oncolytics, 21, 47 - 61
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Tackling HLA Deficiencies Head on with Oncolytic Viruses.
Journal article
Fisher K. et al, (2021), Cancers (Basel), 13
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The role of cancer metabolism in defining the success of oncolytic viro-immunotherapy.
Journal article
Dyer A. et al, (2020), Cytokine Growth Factor Rev, 56, 115 - 123
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A phase 1 trial of the safety, tolerability and biological effects of intravenous Enadenotucirev, a novel oncolytic virus, in combination with chemoradiotherapy in locally advanced rectal cancer (CEDAR).
Journal article
O'Cathail SM. et al, (2020), Radiat Oncol, 15

