Kristijan Ramadan
Professor of Molecular Medicine
- Honorary Senior Researcher - Department of Oncology, University of Oxford
- Medical Research Council (MRC) Investigator
- Corresponding Member of the Croatian Academy of Sciences and Arts
Biography
Kristijan holds degrees in Veterinary Medicine (DVM), Veterinary Pathology (MSc) and PhD in Biochemistry and Molecular Biology under supervision of Prof. Dr. U. Hübscher. He did his post-doctoral training at the ETH-Zürich in the group of Dr H. Meyer. Between 2009 and 2013 he was Junior Group Leader and Lecturer at the Institute of Pharmacology and Toxicology-Vetsuisse, University of Zürich. In 2013 he moved to the UK to join the Department of Oncology as MRC Senior Group leader. From 2014 to 2019 he was Associate Professor at the Department of Oncology, University of Oxford. In 2019 Kristijan was promoted to the Full Professor of Molecular Medicine at University of Oxford.
Kristijan received the Proud of Croatia Award (Croatian Hero for 2014) for his scientific contribution in saving the life of a young boy who suffered from liver cancer caused by mutations in the SPRTN gene.
His work contributed to the discoveries of Chromatin-Associated Degradation, DNA-protein crosslink proteolysis repair and Ruijs-Aalfs Syndrome (RJALS).
In 2020 Kristijan was elected to the Croatian Academy of Sciences and Arts (HAZU) as a distinguished scientist in the field of Medicine.
Recent publications
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The dual ubiquitin binding mode of SPRTN secures rapid spatiotemporal proteolysis of DNA-protein crosslinks
Song W. et al, (2024)
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.
Lascaux P. et al, (2024), Cell, 187, 5698 - 5718.e26
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Isolation and detection of DNA-protein crosslinks in mammalian cells.
Torrecilla I. et al, (2023), Nucleic Acids Res
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Atypical K6-ubiquitin chains mobilize p97/VCP and the proteasome to resolve formaldehyde-induced RNA-protein crosslinks.
Song W. and Ramadan K., (2023), Mol Cell, 83, 4197 - 4199
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ATXN3 controls DNA replication and transcription by regulating chromatin structure.
Hernández-Carralero E. et al, (2023), Nucleic Acids Res