External Funding
Medical Research Council (MRC)
National Institutes of Health (NIH)
Cancer Research UK (CRUK) - RadNet
Collaborators
Professor Crister Ceberg, Lund University
Dr Karl Butterworth, Queen's University Belfast
Dr Jason Parsons, University of Liverpool
Dr Betina Børresen, University of Copenhagen
Dr Anders E Hansen, Technical University of Denmark
Professor Constantinos Koumenis, University of Pennsylvania
Dr Amir Abdollahi, University of Heidelberg
Professor George D. Jones, University of Leicester
Kristoffer Petersson
PhD
MRC Investigator & Group Leader - FLASH Radiation
RESEARCH SUMMARY
FLASH radiation is a novel radiotherapy technique that show great potential in improving cancer treatment. However, very little is known about the biological mechanisms behind the highly beneficial FLASH effect. The research group aims to identify these mechanisms, explain the effect, and to find the optimal way of implementing the technique in clinical practice.
BIOGRAPHY
Kristoffer is a Medical physicist from Helsingborg, Sweden, and holds a M.Sc. (2009) and a Ph.D. (2014) in Medical Radiation Physics from Lund University, Sweden. Kristoffer enjoyed a Post-doc period (2014-2017) working on FLASH radiation at CHUV, in Lausanne, Switzerland. Lately, he has worked as a clinical medical physicist (2017-2019) and started his own research group in FLASH radiotherapy (2017-) at Skåne University Hospital. Recently, Kristoffer accepted the position as Group leader of the newly created research group "Physics and Biology of FLASH Radiation" (2019-) at Oxford Institute for Radiation Oncology, Oxford University.
GROUP MEMBERS
Kyle Hallett, Research Technician
Nathalie Lövgren, DPhil Student
Salomé Paillas, Postdoctoral Researcher
Jia-Ling Ruan, Postdoctoral Researcher
Edward Taylor, DPhil Student
Iain Tullis, Postdoctoral Researcher & Lab manager
MRC Research Programme:
Key publications
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The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Journal article
Vozenin M-C. et al, (2019), Clin Cancer Res, 25, 35 - 42
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Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.
Journal article
Montay-Gruel P. et al, (2017), Radiother Oncol, 124, 365 - 369
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High dose-per-pulse electron beam dosimetry - A model to correct for the ion recombination in the Advanced Markus ionization chamber.
Journal article
Petersson K. et al, (2017), Med Phys, 44, 1157 - 1167
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Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation.
Journal article
Lempart M. et al, (2019), Radiother Oncol, 139, 40 - 45
Recent publications
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FLASH irradiation induces lower levels of DNA damage ex vivo, an effect modulated by oxygen tension, dose, and dose rate.
Journal article
Cooper CR. et al, (2022), Br J Radiol
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In vitro assays for investigating the FLASH effect
Journal article
Adrian G. et al, (2022), Expert Reviews in Molecular Medicine, 24
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The importance of hypoxia in radiotherapy for the immune response, metastatic potential and FLASH-RT
Journal article
OLCINA DEL MOLINO M. et al, (2021), International Journal of Radiation Biology
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Irradiation at ultra-high (FLASH) dose rates reduces acute normal tissue toxicity in the mouse gastrointestinal system.
Journal article
Ruan J-L. et al, (2021), Int J Radiat Oncol Biol Phys
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A focused very high energy electron beam for fractionated stereotactic radiotherapy.
Journal article
Svendsen K. et al, (2021), Sci Rep, 11