Research groups
External Funding
Medical Research Council (MRC)
National Institutes of Health (NIH)
Collaborators
Professor Crister Ceberg, Lund University
Dr Karl Butterworth, Queen's University Belfast
Dr Jason Parsons, University of Birmingham
Dr Betina Børresen, University of Copenhagen
Dr Anders E Hansen, Technical University of Denmark
Professor Constantinos Koumenis, University of Pennsylvania
Dr Amir Abdollahi, University of Heidelberg
Professor Kaye Williams, University of Manchester
Professor Anthony Chalmers, University of Glasgow
Kristoffer Petersson
PhD
MRC Investigator & Group Leader - FLASH Radiation
RESEARCH SUMMARY
FLASH radiation is a novel radiotherapy technique that show great potential in improving cancer treatment. However, very little is known about the biological mechanisms behind the highly beneficial FLASH effect. The research group aims to identify these mechanisms, explain the effect, and to find the optimal way of implementing the technique in clinical practice.
BIOGRAPHY
Kristoffer is a Medical physicist from Helsingborg, Sweden, and holds a M.Sc. (2009) and a Ph.D. (2014) in Medical Radiation Physics from Lund University, Sweden. Kristoffer enjoyed a Post-doc period (2014-2017) working on FLASH radiation at CHUV, in Lausanne, Switzerland. Lately, he has worked as a clinical medical physicist (2017-2019) and started his own research group in FLASH radiotherapy (2017-) at Skåne University Hospital. Since 2019, Kristoffer is Group leader of the research group "Physics and Biology of FLASH Radiation" in the Department of Oncology.
GROUP MEMBERS
Lana Hendrawan, Research Assistant
Nathalie Lövgren, DPhil Student
Salomé Paillas, Postdoctoral Researcher
Jia-Ling Ruan, Postdoctoral Researcher
Sovan Sarkar, Postdoctoral Researcher
Edward Taylor, DPhil Student
Iain Tullis, Postdoctoral Researcher & Lab manager
GROUP ALUMNI & NEXT DESTINATIONS
Dr Christian Cooper, Postdoctoral Researcher (2023-2024) --> Research Scientist at Granza Bio
Key publications
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The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Journal article
Vozenin M-C. et al, (2019), Clin Cancer Res, 25, 35 - 42
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Irradiation in a flash: Unique sparing of memory in mice after whole brain irradiation with dose rates above 100Gy/s.
Journal article
Montay-Gruel P. et al, (2017), Radiother Oncol, 124, 365 - 369
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High dose-per-pulse electron beam dosimetry - A model to correct for the ion recombination in the Advanced Markus ionization chamber.
Journal article
Petersson K. et al, (2017), Med Phys, 44, 1157 - 1167
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Modifying a clinical linear accelerator for delivery of ultra-high dose rate irradiation.
Journal article
Lempart M. et al, (2019), Radiother Oncol, 139, 40 - 45
Recent publications
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The AsiDNA™ decoy mimicking DSBs protects the normal tissue from radiation toxicity through a DNA-PK/p53/p21-dependent G1/S arrest.
Journal article
Sesink A. et al, (2024), NAR Cancer, 6
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Reconfiguring a Plane-Parallel Transmission Ionization Chamber to Extend the Operating Range into the Ultra-High Dose-per-pulse Regime.
Journal article
Konradsson E. et al, (2024), Radiat Res
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Beam control system and output fine-tuning for safe and precise delivery of FLASH radiotherapy at a clinical linear accelerator
Journal article
Konradsson E. et al, (2024), Frontiers in Oncology, 14
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Comparable survival in rats with intracranial glioblastoma irradiated with single-fraction conventional radiotherapy or FLASH radiotherapy
Journal article
Liljedahl E. et al, (2024), Frontiers in Oncology, 13
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Feasibility and constraints of Bragg peak FLASH proton therapy treatment planning.
Journal article
Lövgren N. et al, (2024), Front Oncol, 14