Contact information
Group Members
Callum Beach - join DPhil student with Prof Tim Maughan and Prof Simon Leedham
Hongyu Man - MSc Student
David MacLean - Research Assistant
Collaborators
Monica Olcina
Group Leader - Immune Radiation Biology
Interested in understanding how tumours exploit innate immune pathways to their advantage, and studying how we can target these pathways to improve radiotherapy
Biography
Monica Olcina studied Pharmacy at the University of Manchester. After completing the required training to become a registered pharmacist she moved to Oxford to undertake her Masters and DPhil studies in Radiation Biology. In 2014, she joined Stanford University where she worked as a Cancer Research Institute Irvington Postdoctoral Fellow to identify novel pathways that could be targeted to improve radiotherapy. In 2019 she moved to the University of Zurich to continue these studies. In December 2020 she joined the Oxford Institute for Radiation Oncology as a Junior Group Leader.
MRC RESEARCH PROGRAMME:
Targeting the innate immune stress response to enhance the therapeutic index of radiotherapy
Recent publications
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Intracellular C4BPA Levels Regulate NF-κB-Dependent Apoptosis.
Journal article
Olcina MM. et al, (2020), iScience, 23
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The tumour microenvironment links complement system dysregulation and hypoxic signalling.
Journal article
Olcina MM. et al, (2019), Br J Radiol, 92
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Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer.
Journal article
Olcina MM. et al, (2018), Cell Rep, 25, 3721 - 3732.e6
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Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis.
Journal article
Olcina MM. and Giaccia AJ., (2016), J Clin Invest, 126, 3708 - 3715
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H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK.
Journal article
Olcina MM. et al, (2016), Oncogene, 35, 793 - 799
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Targeting chromatin to improve radiation response.
Journal article
Olcina MM. et al, (2015), Br J Radiol, 88