Sara-Claudia Anghel

Sara is an MSc by Research student  investigating T cell dysfunction and immune regulation in cancer. Her current research focuses on targeting metabolic checkpoints that drive T cell immunosuppression, with the goal of advancing therapeutic strategies that restore anti-tumour immunity.

Before joining the University of Oxford, Sara graduated with First-Class Honours in Biological Sciences (Immunology) with Management from the University of Edinburgh. This interdisciplinary degree reflects her interest in bridging science and business, understanding not only the biological mechanisms of cancer but also how scientific innovation can be translated into healthcare solutions. Sara conducted her undergraduate dissertation in the Philip Lab where she addressed the scarcity of effective conditional protein-regulation technologies in the malaria parasite by adapting two novel protein-degradation systems to Plasmodium berghei.

Beyond that, Sara investigated the genetic foundations of antigen presentation under the supervision of Prof. Jim Kaufman. She has also worked in the laboratory of Prof. Johannes Huppa at the Medical University of Vienna, where she examined TCR–peptide–MHC interactions using lipid bilayer systems and laser microscopy. Prior to this, she contributed to research on the internalisation of pathogenic bacteria in plants at Purdue University in the Deering Lab. In addition to her laboratory work, Sara designed and implemented a pilot Vetiver-based bio–water sanitation system in Peru, in collaboration with the NGO EcoSwell and Engineering for Change.

Alongside her academic pursuits, Sara worked for the cancer documentary “Husky Toni - Go Ahead!”, which follows the inspiring story of a cancer survivor.  Her involvement reflects her passion for connecting science with human stories and public engagement, which has led her to join the committee of the Oxford Society for Science Communication and Engagement.