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DPhil Projects

1. Recombinant Overlapping Peptides as Vaccines for Cancer and Infectious Diseases

2. TNF inflammation associated tumourigenesis

Shisong Jiang

MBBS, PhD

Senior Industrial Fellow

  • Immunology

Therapeutic vaccines; TNF-related inflammation

Research Interests

Research at Dr Jiang’s Laboratory focuses on understanding mechanisms of antigen presentation to the immune system; biomarker discovery and the development of new vaccines, including therapeutic vaccines with a particular emphasis on translating discoveries into new treatments for cancer patients. One major outcome of this work has been the development of a recombinant overlapping peptides technology for cancer therapeutic vaccines and diagnostics. This innovation has led to the formation of a spinout company, Oxford Vacmedix UK Ltd. Two candidates are close to clinical trials. Meanwhile the lab continues to focus on reaching an in-depth understanding of the immune pathways activated by ROPs and identifying additional targets that are amenable to the approach.

Another discovery at Dr Jiang’s Lab is a new biomarker, Inflammation Enhancer (IE). IE is an autoimmune disease factor - together with TNF, IE deteriorates inflammatory diseases such as sepsis and leads to high incidence of fatality. The lab is focusing on elucidating the pathway of IE that leads to inflammation. Diagnostic methods as well as treatments are also in development.

GROUP MEMBERS

Alexander Stephens, DPhil Student

Yuqian Ou, DPhil Student

Sichen Liu, DPhil Student

Constantinos Demetriou, DPhil Student

Cedric Song Chan, MRes Student

Group Alumni & Next Destinations

Jian Wang - Associate Professor, Southwest University, Chongqing, China

Rong Hu, Attending Doctor,  Assistant Professor, Department of Otolaryngology Beijing

Tongren Hospital, Capital Medical University, China

Sophie Owen - PhD Tropical Medicine, Liverpool School of Tropical Medicine, UK

Wenshu Lu - CEO, Shanghai Inflinhix Ltd

Neha Vashist-Postdoctoral Researcher, Würzburg, Bavaria, Germany

Jason Huang - Associate Medical Director, Oncology, Asia-Pacific at Merck Group, Singapore

Qiongyu Chen - USA

Hongwei Zhang - Associate Chief Physician, Beijing You'an Hospital, Capital Medical University, China

Hai Hong - Associate Professor, Sun Yat-Sen University, China

Key publications

Recent publications

More publications