Shisong Jiang

MBBS, PhD

Group Leader

Immunology

Therapeutic vaccines; TNF-related inflammation

Research Interests

Research at Dr Jiang’s Laboratory focuses on understanding mechanisms of antigen presentation to the immune system; biomarker discovery and the development of new vaccines, including therapeutic vaccines with a particular emphasis on translating discoveries into new treatments for cancer patients. One major outcome of this work has been the development of a recombinant overlapping peptides technology for cancer therapeutic vaccines and diagnostics. This innovation has led to the formation of a spinout company, Oxford Vacmedix UK Ltd. Two candidates are close to clinical trials. Meanwhile the lab continues to focus on reaching an in-depth understanding of the immune pathways activated by ROPs and identifying additional targets that are amenable to the approach.

Another discovery at Dr Jiang’s Lab is a new biomarker, Inflammation Enhancer (IE). IE is an autoimmune disease factor - together with TNF, IE deteriorates inflammatory diseases such as sepsis and leads to high incidence of fatality. The lab is focusing on elucidating the pathway of IE that leads to inflammation. Diagnostic methods as well as treatments are also in development.

GROUP MEMBERS

Alexander Stephens, DPhil Student

Yuqian Ou, Research Assistant

Rong Hu, Visiting Scholar

GROUP ALUMNI & NEXT DESTINATIONS

Sophie Owen - PhD Tropical Medicine, Liverpool School of Tropical Medicine, UK

Wenshu Lu - CEO, Shanghai Inflinhix Ltd

Neha Vashist-Postdoctoral Researcher, Würzburg, Bavaria, Germany

Jason Huang - Associate Medical Director, Oncology, Asia-Pacific at Merck Group, Singapore

Qiongyu Chen - USA

Hongwei Zhang - Associate Chief Physician, Beijing You'an Hospital, Capital Medical University, China

Hai Hong - Associate Professor, Sun Yat-Sen University, China

Key publications

Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells.
Journal article

Zhang H. et al, (2009), J Biol Chem, 284, 9184 - 9191

Recent publications

TNF-derived peptides inhibit tumour growth and metastasis through cytolytic effects on tumour lymphatics.
Journal article

Lu W. et al, (2019), Clin Exp Immunol
ANTIBODY FACILITATING PROGRAMMED NECROSIS OF CELLS AND APPLICATION THEREOF
Patent

JIANG S. and Lu W., (2018)
PROTEIN FOR NEUTRALIZING PROGRAMMED NECROCYTOSIS PROMOTION ANTIBODY, AND APPLICATION OF PROTEIN
Patent

JIANG S. and Lu W., (2018)
Protective cellular immunity generated by cross-presenting recombinant overlapping peptide proteins.
Journal article

Cai L. et al, (2017), Oncotarget, 8, 76516 - 76524
ARTIFICIAL MULTI-ANTIGEN FUSION PROTEIN AND PREPARATION AND USE THEREOF
Patent

JIANG S. et al, (2017)
A DC vaccine and its preparation method and applications
Patent

Weixing S. et al, (2014)
Overlapping peptides taken as reagents for skin tests detecting specific cellular immune and applications
Patent

JIANG S., (2013)
TNF-alpha short peptide- related to apoptosis or necrosis and applications thereof
Patent

JIANG S., (2012)
Depletion of CD4+CD25+ regulatory T cells enhances natural killer T cell-mediated anti-tumour immunity in a murine mammary breast cancer model.
Journal article

Hong H. et al, (2010), Clin Exp Immunol, 159, 93 - 99
Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells.
Journal article

Zhang H. et al, (2009), J Biol Chem, 284, 9184 - 9191
Comparing pooled peptides with intact protein for accessing cross-presentation pathways for protective CD8+ and CD4+ T cells.
Journal article

JIANG S., (2009), Journal of Biological Chemistry
Live attenuated Listeria monocytogenes expressing HIV Gag: Immunogenicity in rhesus monkeys
Journal article

Jiang S. et al, (2007), Vaccine, 25, 7470 - 7479
Overlapping synthetic peptides as vaccines
Journal article

Jiang S. et al, (2006), Vaccine, 24, 6356 - 6365
Schistosoma mansoni infection promotes SHIV clade C replication in rhesus macaques
Journal article

Chenine A-L. et al, (2005), AIDS, 19, 1793 - 1797
Compositions and methods for modulating a cytotoxic T lymphocyte immune response
Patent

JIANG S. and Ruprecht R., (2005)
Postnatal pre- and postexposure passive immunization strategies: protection of neonatal macaques against oral simian-human immunodeficiency virus challenge
Journal article

Hofmann-Lehmann R. et al, (2002), Journal of Medical Primatology, 31, 109 - 119

More publications