Tim Humphrey
Honorary Senior Researcher, Department of Oncology
- Professor of Molecular Genetics
Research Summary
The aim of my research is to understand how genome stability is maintained in response to DNA double-strand breaks, and to exploit the findings to target cancer.
Biography
Tim performed his doctoral studies at the University of Oxford and was an EMBO and HFSP post-doctoral research fellow at Harvard Medical School before returning to the UK to become a group leader at the MRC Genome Stability Unit, Oxfordshire. He was awarded tenure in 2003, and in 2008 he moved to the Gray Institute in Oxford and heads the Chromosome Integrity Group.
Recent publications
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The Challenge of Combining Chemo- and Radiotherapy with Checkpoint Kinase Inhibitors.
van Bijsterveldt L. et al, (2020), Clin Cancer Res
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An essential role for dNTP homeostasis following CDK-induced replication stress.
Pai C-C. et al, (2019), J Cell Sci
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Nucleoporin 54 contributes to homologous recombination repair and post-replicative DNA integrity.
Rodriguez-Berriguete G. et al, (2018), Nucleic Acids Res, 46, 7731 - 7746
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Analysis of DNA Metabolism in Fission Yeast.
Antequera F. and Humphrey TC., (2018), Cold Spring Harb Protoc, 2018
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DNA Double-Strand Break Repair Assay.
Pai C-C. et al, (2018), Cold Spring Harb Protoc, 2018