Research groups
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Collaborators
Prof. Eileen Parkes, University of Oxford, UK
Prof. Nnennaya Kanu, University College London, UK
Prof. Fabrice André, Institut Gustave Roussy, France (SCANDARE cohort)
Prof. Christophe Le Tourneau, Institut Curie, France (SCANDARE cohort)
Dr. Monica Arnedos, Bordeaux Institute of Oncology, France (SCANDARE cohort)
Prof. Sherene Loi, Peter MacCallum Cancer Centre, Australia (kConFab cohort)
Dr Heather Thorne, Peter MacCallum Cancer Centre, Australia (kConFab cohort)
Wei-Ting Lu
BSc, PhD
Group Leader - Chromosomal Instability in Cancer
Biography
Originally from Taiwan, Wei-Ting spent most of his childhood in the Malaysian island of Borneo. He did his undergraduate and PhD studies at the University of Sheffield, focusing on genome instability. Wei-Ting then joined the group of Prof. Martin Bushell where he investigated how non-coding RNAs and DNA-RNA hybrids are regulated to maintain genome stability. In 2018, Wei-Ting joined the group of Prof. Charles Swanton at the Crick Institute, where he led the functional characterisation of cancer drivers identified in the TRACERx lung cancer cohort. In September 2025, he joined the Department of Oncology as a Group Leader, studying the molecular processes contributing to whole genome doubling and chromosomal instability.
Research Summary
Normally, we store our genetic information in 23 pairs of chromosomes. However, cancer cells seldom conform to this number. Rather, cancer cells undergo whole genome doubling to duplicate all their 23 pairs of chromosomes to 46 pairs in one fell swoop. Following this, mutations and chromosomal rearrangements occur repeatedly in cancer cells, resulting in a population of highly variable chromosomal numbers. These events correlate with worse clinical outcomes, drug resistance and cancer metastasis.
Using existing population genomic and clinical data, our lab aims to functionally characterise the events that contribute to whole genome doubling and chromosomal instability. We are interested in FAT protocadherins, a class of proteins which are often mutated in lung, breast, skin and oesophageal cancers. By understanding the role played by the FAT proteins, we aim to find novel treatment strategies.
Key publications
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TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.
Journal article
Lu W-T. et al, (2025), Nat Cell Biol, 27, 154 - 168
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FAT1 alterations contribute to chromosomal instability in cancer cells.
Journal article
(2025), Nat Cell Biol, 27, 12 - 13
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Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution.
Journal article
Venkatesan S. et al, (2021), Cancer Discov, 11, 2456 - 2473
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Drosha drives the formation of DNA:RNA hybrids around DNA break sites to facilitate DNA repair.
Journal article
Lu W-T. et al, (2018), Nat Commun, 9
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The emerging role of RNAs in DNA damage repair.
Journal article
Hawley BR. et al, (2017), Cell Death Differ, 24, 580 - 587
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Translational repression and eIF4A2 activity are critical for microRNA-mediated gene regulation.
Journal article
Meijer HA. et al, (2013), Science, 340, 82 - 85
Recent publications
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DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution.
Journal article
Gimeno-Valiente F. et al, (2025), Nat Genet, 57, 2226 - 2237
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Subclonal immune evasion in non-small cell lung cancer.
Journal article
Dijkstra KK. et al, (2025), Cancer Cell
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ImmuneLENS characterizes systemic immune dysregulation in aging and cancer.
Journal article
Bentham R. et al, (2025), Nat Genet, 57, 694 - 705
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FAT1 alterations contribute to chromosomal instability in cancer cells.
Journal article
(2025), Nat Cell Biol, 27, 12 - 13
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Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Journal article
Biswas D. et al, (2025), Nat Cancer, 6, 86 - 101
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TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.
Journal article
Lu W-T. et al, (2025), Nat Cell Biol, 27, 154 - 168