Yanyan Jiang
BSc, MSc, Dphil
Senior Research Associate
Tumour microenvironment & translational cancer therapy
RESEARCH SUMMARY
Yanyan Jiang’s research is focused on identifying novel therapies for lung cancer by targeting the DNA damage response and tumour microenvironment (in particular hypoxia).
BIOGRAPHY
Yanyan Jiang received her BSc in pharmacy and MSc in Pharmacology from China. She then completed her DPhil study in Pharmacology at University of Oxford in 2008. Afterwards Yanyan undertook postdoctoral work in the Cardiovascular Department, University of Oxford. In 2011 Yanyan joined the Oncology Department, University of Oxford. In addition to her research, Yanyan also teaches MSc in Radiation Biology in the Department.
Recent publications
-
Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Beach C. et al, (2023), J Clin Invest, 133
-
CHK1 inhibition exacerbates replication stress induced by IGF blockade.
Wu X. et al, (2021), Oncogene
-
DNAPK inhibition preferentially compromises the repair of radiation-induced DNA double-strand breaks in chronically hypoxic tumor cells in xenograft models.
Jiang Y. et al, (2021), Mol Cancer Ther
-
Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model.
Jiang Y. et al, (2021), Br J Cancer, 124, 1809 - 1819
-
Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response.
Zhang P. et al, (2021), Cancer Res, 81, 1667 - 1680
-
Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
Willoughby CE. et al, (2020), J Clin Invest, 130, 258 - 271
-
RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma.
Pankova D. et al, (2019), EMBO J
-
Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.
Mumin NH. et al, (2019), BMC Cancer, 19
-
PARP Inhibition Combined With Thoracic Irradiation Exacerbates Esophageal and Skin Toxicity in C57BL6 Mice.
Lourenco LM. et al, (2018), Int J Radiat Oncol Biol Phys, 100, 767 - 775
-
Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Jiang Y. et al, (2016), Int J Radiat Oncol Biol Phys, 95, 772 - 781