Yanyan Jiang
BSc, MSc, Dphil
Senior Research Associate
Tumour microenvironment & translational cancer therapy
RESEARCH SUMMARY
Yanyan Jiang’s research is focused on identifying novel therapies for lung cancer by targeting the DNA damage response and tumour microenvironment (in particular hypoxia).
BIOGRAPHY
Yanyan Jiang received her BSc in pharmacy and MSc in Pharmacology from China. She then completed her DPhil study in Pharmacology at University of Oxford in 2008. Afterwards Yanyan undertook postdoctoral work in the Cardiovascular Department, University of Oxford. In 2011 Yanyan joined the Oncology Department, University of Oxford. In addition to her research, Yanyan also teaches MSc in Radiation Biology in the Department.
Recent publications
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Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.
Journal article
Beach C. et al, (2023), J Clin Invest, 133
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CHK1 inhibition exacerbates replication stress induced by IGF blockade.
Journal article
Wu X. et al, (2021), Oncogene
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DNAPK inhibition preferentially compromises the repair of radiation-induced DNA double-strand breaks in chronically hypoxic tumor cells in xenograft models.
Journal article
Jiang Y. et al, (2021), Mol Cancer Ther
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Olaparib increases the therapeutic index of hemithoracic irradiation compared with hemithoracic irradiation alone in a mouse lung cancer model.
Journal article
Jiang Y. et al, (2021), Br J Cancer, 124, 1809 - 1819
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Germline and Somatic Genetic Variants in the p53 Pathway Interact to Affect Cancer Risk, Progression, and Drug Response.
Journal article
Zhang P. et al, (2021), Cancer Res, 81, 1667 - 1680
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Selective DNA-PKcs inhibition extends the therapeutic index of localized radiotherapy and chemotherapy.
Journal article
Willoughby CE. et al, (2020), J Clin Invest, 130, 258 - 271
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RASSF1A controls tissue stiffness and cancer stem-like cells in lung adenocarcinoma.
Journal article
Pankova D. et al, (2019), EMBO J
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Overcoming acquired resistance to HSP90 inhibition by targeting JAK-STAT signalling in triple-negative breast cancer.
Journal article
Mumin NH. et al, (2019), BMC Cancer, 19
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PARP Inhibition Combined With Thoracic Irradiation Exacerbates Esophageal and Skin Toxicity in C57BL6 Mice.
Journal article
Lourenco LM. et al, (2018), Int J Radiat Oncol Biol Phys, 100, 767 - 775
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Hypoxia Potentiates the Radiation-Sensitizing Effect of Olaparib in Human Non-Small Cell Lung Cancer Xenografts by Contextual Synthetic Lethality.
Journal article
Jiang Y. et al, (2016), Int J Radiat Oncol Biol Phys, 95, 772 - 781